Toxicology Assessment of Ocimum tenuiflorum L. Leaves Extracts on Streptozotocin-Induced Diabetic Rats

Leila Mousavi, Rabeta Mohd Salleh*, Vikneswaran Murugaiyah

  • Rabeta Mohd Salleh

Abstract

Toxicology Assessment of Ocimum tenuiflorum L. Leaves Extracts on Streptozotocin-Induced Diabetic Rats 

Leila Mousavi1, Rabeta Mohd Salleh*1, Vikneswaran Murugaiyah2

1Food Technology Division, School of Industrial Technology, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.

2Discipline of Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia

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Abstract

The present study was aimed out to investigate the effects of different solvent extracts from Ocimum tenuiflorum L. leaves on lipid profile, liver function, and kidney functions of streptozotocin-induced diabetic rats and toxicology assessment. In this study Ocimum tenuiflorum leaves solvent crude extracts were used for an acute test for 14th days. Diabetes was induced in Spargue-Dawley rats by intraperitoneal (i.p.) injection of streptozotocin. All the diabetic rats were under treated by oral admonition of extracts (1000 mg/kg) for fourteen days. After 14th days of treatment blood was withdrawn for biochemical and haematological tests. Kidney, pancreas and liver discarded for histopathology assessment of toxicity effect on organs. Blood glucose level and other biochemical measurements in streptozotocin-induced rats compared with the control group showed fluctuating levels in a different parameter. Histological analysis of tissues indicated there were no adverse changes in the liver, kidneys, and pancreas compared to the control group. According to our result, Ocimum tenuiflorum methanol leaf extract as a medium polarity solvent extract had possibly exerts of an antihyperglycaemic effects through major bioactive compounds that be able to control diabetes. A clinical study is needed to confirm the antidiabetic potential of this plant.

Keywords:  Biochemical, Histopathology, Haematology parameters, Ocimum tenuiflorum L., Sprague Dawley rats, streptozotocin (STZ)

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ARTICLE INFO

Received 15th November 2018

Received in revised form 17th December 2018

Accepted 17th December 2018

*Corresponding author: Dr Rabeta Mohd Salleh

Tel: ++604 653 5211  e mail: rabeta@usm.edu.my

Copyright Malaysian Journal of Microscopy (2018). All rights reserved. ISSN: 1823-7010 eISSN 2600-7444

Published
2018-12-31
Section
Original Research Articles